Limbic wiki map

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This page is a hybrid of an open ended circuit diagram with hyperlinks which point to the wiki underneath which in turn points to references which back up the connections. Think of google maps meets wikipedia.

The main aim is to have a circuit diagram which is supported by references which then informs computer models which simulate behavioural experiments.

Ideally this should work as follows:

  1. Take a behavioural experiment, for example a rat needs to wait in front of a food dispenser
  2. Take the limbic circuit diagram above and create a simulated rat doing that behaviour
  3. Make predictions for new experiments / interventions
  4. Update diagram
  5. go back to 1)

In conjunction to this there is a blog https://limbic-system-site.blogspot.co.uk/ which talks about this site mainly in the light of simulations generated by a simple behavioural simulator.

Nuclei

Review articles

  1. This article by Castro and Berridge promotes their long standing differentiation between 'wanting' and 'liking' (Kent C. Berridge, 2009) now updated by 'hedonic hot spots' (Daniel C. Castro, Shannon L. Cole, Kent C. Berridge, 2015).
  2. Berthoud's article features fantastic connection diagrams between the different nuclei of the limbic system (HR. Berthoud, 2004).
  3. Zahm again provides very detailed anatomical connection diagrams and is a must read (DS. Zahm, 2000).
  4. The review by Abbas Khani and Gregor Rainer focusses on the roles of the different nuclei, how they interact, how they implement reinforcement guided decision making and which forms are out there (reversal, go no go etc). A very balanced article which, for example, not just cites the prediction error paradigm of DA but reports also the other roles DA (Abbas Khani, Gregor Rainer, 2016).

Based on research conducted by

  • Bernd Porr
  • Ailsa Millen
  • Graeme Hattan
  • Maria Thomson
  • Marc Sutherland.

Contact: Bernd.Porr@glasgow.ac.uk


Berridge2009 Kent C. Berridge, Jul 2009. 'Liking' and 'wanting' food rewards: brain substrates and roles in eating disorders.. Physiology \& behavior, 97, pp.537–550, ISSN 1873-507X.
Castro2015 Daniel C. Castro, Shannon L. Cole, Kent C. Berridge, Jun 2015. Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry.. Frontiers in systems neuroscience, 9, pp.90, ISSN 1662-5137.
Berthoud04 HR. Berthoud, Jul 2004. Mind versus metabolism in the control of food intake and energy balance. Physiol Behav, 81, pp.781-793.
Zahm00 DS. Zahm, Jan 2000. An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neurosci Biobehav Rev, 24, pp.85-105.
Khani2016 Abbas Khani, Gregor Rainer, Aug 2016. Neural and neurochemical basis of reinforcement-guided decision making.. Journal of neurophysiology, 116, pp.724–741, ISSN 1522-1598.